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| New general concept for the treatment of cancer Posted: 03 Apr 2014 05:25 AM PDT A team of researchers from five Swedish universities, led by Karolinska Institutet and the Science for Life Laboratory, have identified a new way of treating cancer. The concept is presented in the journal Nature and is based on inhibiting a specific enzyme called MTH1, which cancer cells, unlike normal cells, require for survival. Without this enzyme, oxidized nucleotides are incorporated into DNA, resulting in lethal DNA double-strand breaks in cancer cells. |
| Vitamin A may be able to rescue pre-cancerous breast epithelial cells Posted: 02 Apr 2014 07:39 PM PDT Cell culture studies suggest that vitamin A derivatives can reverse pre-malignant lesions to normality, but only has a small window of opportunity as it has no impact on invasive or tumorigenic stage cells. These are the findings of a new study from researchers in Thomas Jefferson University in Philadelphia and the University of Chicago, published early online in the International Journal of Oncology. |
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